Launch from Cape Canaveral (KSC), Launch Complex 39A at NASA's Kennedy Space Center in Florida. The Crew Dragon Freedom docked 16 hours later with the International Space Station. The spacecraft landed 122 km southwest of Panama City / Florida in the Gulf of Mexico.

The four-person multinational astronaut crew of Ax-2 will conduct more than 20 different experiments while aboard the space station, made possible by NASA Space's full-service integration into the NASA process for science and technology activities onboard the ISS. Data collected in-flight will impact understanding of human physiology on Earth and on-orbit, as well as establish the utility of novel technologies that could be used for future human spaceflight pursuits and humankind on Earth. Axiom Space's partnerships offer the opportunity to expand the commercial space economy and support commercial innovations and manufacturing of biomedical products and advanced materials in low-Earth orbit.